NT-proBNP (1-76)
Produktdaten
Précautions
Centrifuge freshly collected blood as soon as possible. Store centrifuged samples at -20°C for longer storage. Samples are stable up to 3 freeze and thaw cycles. Hemolyzed or lipemic samples may cause erroneous results.
Valeurs de référence
Median Serum (n=70): 5.8 pmol/l Median EDTA plasma (n=28): 5.6 pmol/l
| Nom du produit | NT-proBNP (1-76) |
| Cat. no | SK-1204 |
| Gamme | 0 – 640 pmol/l |
| Sensibilité | 3.3 pmol/l (STD2 10 pmol/l) |
| Durée d'incubation | 3 h / 30 min |
| Volume échantillon | 50 μl |
| Echantillon | Serum, EDTA plasma |
| Tests | 96 |
| Méthode | ELISA |
Intérêt clinique
Intended use:
BNP is mainly expressed by ventricular myocardium in response to volume overload and increased filling pressure. BNP has a cleavable signal sequence. Mature BNP consists of 108 amino acids (proBNP or BNP- 108), and undergoes cleavage resulting in physiologically active BNP-32 and additional C-terminal fragments (cf. http://www.uniprot.org/uniprot/P16860#PRO_0000001532), along with a physiologically inactive N- terminal peptide comprising amino acids 1-76, which is further degraded proteolytically. BNP has a key role in cardiovascular homeostasis with biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. A high concentration of BNP in the bloodstream is indicative of heart failure.
Intended applications:
- Cardiac impairment, acute myocardial infarction, (left ventricular dysfunction)
- Renal failure
- Obesity and diabetes
- Various forms of secondary hypertensions
- Therapy monitoring of heart failure patients
