Métabolisme osseux

Nom du produit

DKK-1

Dickkopf-1

Cat. noBI-20413
Gamme0 – 160 pmol/l
Sensibilité1.25 pmol/l (STD2 10 pmol/l)
Durée d'incubation3.5 hours
Volume échantillon20 µl
Echantillon

Serum

Précautions

Centrifuge freshly collected blood as soon as possible
Store centrifuged samples at -20°C for longer storage.
Samples are stable up to 3 freeze and thaw cycles.
Hemolyzed or lipemic samples may cause erroneous results.

Valeurs de référence

Median = 34 pmol/l (n = 51)

Espèces

Human

Tests96
MéthodeELISA
Intérêt clinique

Intended use:

Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.

Intended applications:

Atherosclerosis
Rheumatoid arthritis
Myeloma bone disease
Diffuse idiopathic skeletal hyperostosis
Ankylosing spondylitis
Monoclonal gammopathy of undetermined significance
Glucocorticoid induced osteoporosis
Oncology

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