DKK-1
Produktdaten
Dickkopf-1
Précautions
Centrifuge freshly collected blood as soon as possible
Store centrifuged samples at -20°C for longer storage.
Samples are stable up to 3 freeze and thaw cycles.
Hemolyzed or lipemic samples may cause erroneous results.
Valeurs de référence
Median = 34 pmol/l (n = 51)
| Nom du produit | DKK-1 |
| Cat. no | BI-20413 |
| Gamme | 0 – 160 pmol/l |
| Sensibilité | 1.25 pmol/l (STD2 10 pmol/l) |
| Durée d'incubation | 3.5 hours |
| Volume échantillon | 20 µl |
| Echantillon | Serum |
| Espèces | Human |
| Tests | 96 |
| Méthode | ELISA |
Intérêt clinique
Intended use:
Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.
Intended applications:
Atherosclerosis
Rheumatoid arthritis
Myeloma bone disease
Diffuse idiopathic skeletal hyperostosis
Ankylosing spondylitis
Monoclonal gammopathy of undetermined significance
Glucocorticoid induced osteoporosis
Oncology