Calcium metabolism

Product name

Human Fetuin-A

Range12.5 - 370 ng/ml
Sensitivity5.0 ng/ml
Incubation time3 hours
Sample volume10 µl (dilute 1:10.000)
Sample type


Sample preparation

Serum should be separated within 3 hours after blood collection,
measure or store at -20°C. Max. 3 freeze and thaw cycles.

Reference values
range (g/l) Mean (g/l) SD (g/l)
0.35 - 0.95 0.57 0.13




Intended use

Fetuin-A synthesized in the liver is secreted into the blood stream and it is deposited, accumulated as a noncollagenous protein in mineralized bones and teeth. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, a frequently seen complication in degenerative diseases. Low Fetuin-A level may be associated with higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis.
Human Fetuin-A represents a natural inhibitor of tyrosine kinase activity of the insulin receptor. Fetuin-A may play a significant role in regulating post-prandial glucose disposition, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions.
• Fetuin-A level (< 0.35 g/l) indicates a higher risk of cardiovascular calcification and increase mortality in ESRD-patients.
• Fetuin-A level (> 1.00 g/l) in elderly population, an independent risk factor of type II diabetes.
• Fetuin-A is an important predictor of death in acute myocardial infarction.
• Involved with the regulation of calcium metabolism and osteogenesis.

Product informations

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