Bone metabolism

Product name

Sclerostin TECO® High sensitive

Regulation of Bone Turnover.

Cat-Nr.

TE1023-HS

Range

0.05 – 3 ng/ml

Sensitivity

LOD: 0.009 ng/ml
LLOQ: 0.058 ng/ml
LOQ: 3.5 ng/ml

Incubation time

4.5 hours

Sample volume

25 µl

Sample type

Plasma, Serum, Cell culture

Sample preparation

Samples should be collected without hemolysis. Allow the blood to clot, separate serum by centrifugation and test samples within 2 hours.
Serum is stable for 3 days at room temperature, 5 days at 2 – 8 °C, 2 years at -20 °C.
Longer storage at -80°C. Maximum 3 freeze- and thaw cycles.

Reference values

Sclerostin Values are dependent on age and gender.

Subjects	Mean (ng/ml)	SD (ng/ml)	Mean (pmol/l)	SD (pmol/l)	N
Pre-menopausal female	0.48	0.14	21.12	6.16	20
Post-menopausal female	0.58	0.17	25.52	7.48	19
Men	0.64	0.15	38.16	6.6	10

Clinically Healthy Subjects

Species

Human

Tests

Method

ELISA

Intended use

• Sclerosteosis
• Van Buchem disease
• Osteoporosis
• Chronic Kidney Disease
• Cardiac Research
• Others

Product informations

Instruction for Use (PDF 821.5 KB)

Product Specifications (PDF 258.1 KB)

Techn. & clin. Bulletin (PDF 2.5 MB)

Sclerostin is the protein product of the SOST gene and inhibits bone formation by regulating osteoblast function and promoting osteoblast apoptosis. Reduced expression of sclerostin can result in van Buchem disease, while a complete absence of Sclerostin results in Sclerosteosis. Our Human Sclerostin High Sensitivity (HS)ELISA is designed for the measurement of Sclerostin in human serum, plasma and cell culture (osteocytes and chondrocytes).

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