Bone metabolism

N-terminal Telopeptide of Collagen Type-I

Serum, cell culture

Specimen should be collected at the same time of the day. Store samples refrigerated at 2-8°C for up to 24 hours or frozen at -20 °C for longer storage. Stable up to 3 freeze and thaw cycles.

nmol Bone Collagen Equivalents per litre = nM BCE 

Reference values from children are available.

Human, bovine, sheep, porcine, rabbit, rat, rhesus macaque

Osteomark® NTX-Serumtest is used for the quantitative management of cross-linked N-telopeptides of type I collagen in human serum. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.

NTX levels are used for:
- monitoring of antiresorptive therapy in osteoporosis
- Paget’s disease
- monitoring and early detection of bone metastasis.