N-terminal Telopeptide of Collagen Type-I
Specimen should be collected at the same time of the day. Store samples refrigerated at 2-8°C for up to 24 hours or frozen at -20 °C for longer storage. Stable up to 3 freeze and thaw cycles.
nmol Bone Collagen Equivalents per litre = nM BCE
|Mean||SD|| Range |
(mean ± 2 SD)
|Premenopausal women |
(25 - 49 years)
|12.6||3.2||6.2 - 19.0|
|Postmenopausal women||12.9 - 22.7|
|Men (31 - 80 years)||14.8||4.7||5.4 - 24.2|
Reference values from children are available.
|Range||5 - 40 nM BCE|
|Sensitivity||3.2 nM BCE|
|Incubation time||2 hours|
|Sample volume||50 µl (dilute 1:5)|
Serum, cell culture
Human, bovine, sheep, porcine, rabbit, rat, rhesus macaque
NTX-Serumtest is used for the quantitative management of cross-linked N-telopeptides of type I collagen in human serum. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.
NTX levels are used for:
- monitoring of antiresorptive therapy in osteoporosis
- Paget’s disease
- monitoring and early detection of bone metastasis.