N-terminal Telopeptide of Collagen Type-I

Sample preparation

Specimen should be collected at the same time of the day. Store samples refrigerated at 2-8°C for up to 24 hours or frozen at -20 °C for longer storage. Stable up to 3 freeze and thaw cycles.

Reference values

nmol Bone Collagen Equivalents per litre = nM BCE 

  Mean SD  Range
(mean ± 2 SD)
Premenopausal women
(25 - 49 years)
12.6 3.2 6.2 - 19.0
Postmenopausal women     12.9 - 22.7
 Men (31 - 80 years) 14.8 4.7 5.4 - 24.2

Reference values from children are available.

Product name NTX-Serum
Cat-Nr. 9021
Range 5 - 40 nM BCE
Sensitivity 3.2 nM BCE
Incubation time 2 hours
Sample volume 50 µl (dilute 1:5)
Sample type

Serum, cell culture


Human, bovine, sheep, porcine, rabbit, rat, rhesus macaque

Tests 96 Tests
Method ELISA

Intended use

NTX-Serumtest is used for the quantitative management of cross-linked N-telopeptides of type I collagen in human serum. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.

NTX levels are used for:

  • monitoring of antiresorptive therapy in osteoporosis
  • Paget’s disease
  • monitoring and early detection of bone metastasis.

Product informations