Oxidative Stress & Cardiovascular Disease
Product name | NT-proBNP (1-76) |
Cat-Nr. | SK-1204 |
Range | 0 – 640 pmol/l |
Sensitivity | 3.3 pmol/l (STD2 10 pmol/l) |
Incubation time | 3 h / 30 min |
Sample volume | 50 μl |
Sample type | Serum, EDTA plasma |
Sample preparation | Centrifuge freshly collected blood as soon as possible. |
Reference values | Median Serum (n=70): 5.8 pmol/l Median EDTA plasma (n=28): 5.6 pmol/l |
Species | Human |
Tests | 96 |
Method | ELISA |
Intended use | Intended use: BNP is mainly expressed by ventricular myocardium in response to volume overload and increased filling pressure. BNP has a cleavable signal sequence. Mature BNP consists of 108 amino acids (proBNP or BNP- 108), and undergoes cleavage resulting in physiologically active BNP-32 and additional C-terminal fragments (cf. http://www.uniprot.org/uniprot/P16860#PRO_0000001532), along with a physiologically inactive N- terminal peptide comprising amino acids 1-76, which is further degraded proteolytically. BNP has a key role in cardiovascular homeostasis with biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. A high concentration of BNP in the bloodstream is indicative of heart failure. Intended applications:
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Product informations |