Bone metabolism

Product name

OPG, Human


Range1.5 – 60 pmol/l
SensitivityAnalytical: 0.13 pmol/l; Assay: 0.4 pmol/l
Incubation time3 hours
Sample volume100 µl (dilute 1:3, cell culture direct)
Sample type

Serum, plasma (EDTA, Citrate, Heparin), cell culture, synovial fluid

Sample preparation

No activity loss for 8 hours at room temperature or up to 2 weeks at
4 °C. Store samples at -20 °C for longer storage. Serum is stable up to 3 freeze and thaw cycles, Heparin only stable for 1 freeze and thaw cycle. Before use, thaw samples at low temperature and mix them thoroughly. Hemolyzed or lipemic sera may cause erroneous results.

Reference values

Average 5.7 ± 0.42 pmol/l


Human, baboon, rhesus macaque

Tests96 Tests
Intended use

Osteoprotegerin (OPG) is a secretory glycoprotein belonging to the TNF receptor super family. OPG inhibits the binding of RANK to RANKL and thus inhibits the recruitment, proliferation and activation of osteoclasts. Since OPG exhibits an inhibitory effect on osteoclasts activation, it acts as a soluble factor in the regulation of bone mass. Changes in the homeostasis of the RANKL/RANK/OPG systems causes disturbances in bone remodeling shown by bone damages in patients with postmenopausal osteoporosis, Paget’s disease, bone loss due to cancer metastases and rheumatoid arthritis.
Intended applications:

  • Postmenopausal and senile osteoporosis
  • Glucocorticoid dependent osteoporosis
  • Diseases with locally increased resorption activity
  • Therapy control of OPG treatments
  • Arthritis
  • Bone metastases
  • Vascular calcification
  • Renal cell carcinoma

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