N-Terminal Telopeptide of Type I Collagen

Sample preparation

Collect second void of morning urine or 24 hours urine without adding preservatives. Fasting sample collection is not required.
Samples are stable at room temperature for 24 hours or refrigerated
at 2-8 °C for up to 72 hours. Longer storage at -20°C. Stable up to 3 freeze and thaw cycles.

Reference values

nmol Bone Collagen Equivalents/l (nM BCE)
per mmol Creatinine/l = nM BCE / mM Creatinine

  Mean Range (± 2 SD)
Premenopausal women (25 - 49 yrs) 35 5 - 65
Men (31 - 87 yrs) 33 3 - 63

Reference values from children are available.

Product name NTX-Urine
Cat-Nr. 9006
Range 20 - 3000 nM BCE
Sensitivity 20 nM BCE (value not corrected for creatinine)
Incubation time 2 hours
Sample volume 25 µl
Sample type

Urine, cell culture


Human, dog, porcine, rat, bovine and rhesus macaque

Tests 96 Tests
Method ELISA

Intended use

NTX-Urine test is used for the quantitative measured of cross-linked N-telopeptides of type I collagen in urine. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.

NTX-levels are used for:

  • monitoring of antiresorptive therapy in osteoporosis
  • Paget’s disease
  • monitoring and early detection of bone metastasis

Product informations