Sample preparation

Centrifuge freshly collected blood as soon as possible
Store centrifuged samples at -20°C for longer storage.
Samples are stable up to 3 freeze and thaw cycles.
Hemolyzed or lipemic samples may cause erroneous results.

Reference values

Median = 34 pmol/l (n = 51)

Product name DKK-1
Cat-Nr. BI-20413
Range 0 – 160 pmol/l
Sensitivity 1.25 pmol/l (STD2 10 pmol/l)
Incubation time 3.5 hours
Sample volume 20 µl
Sample type




Tests 96
Method ELISA

Intended use

Intended use:

Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.

Intended applications:

  • Atherosclerosis
  • Rheumatoid arthritis
  • Myeloma bone disease
  • Diffuse idiopathic skeletal hyperostosis
  • Ankylosing spondylitis
  • Monoclonal gammopathy of undetermined significance
  • Glucocorticoid induced osteoporosis
  • Oncology

Product informations