Bone metabolism

Dickkopf-1

Serum

Centrifuge freshly collected blood as soon as possible
Store centrifuged samples at -20°C for longer storage.
Samples are stable up to 3 freeze and thaw cycles.
Hemolyzed or lipemic samples may cause erroneous results.

Median = 34 pmol/l (n = 51)

Human

Intended use:

Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.

Intended applications:

• Atherosclerosis
• Rheumatoid arthritis
• Myeloma bone disease
• Diffuse idiopathic skeletal hyperostosis
• Ankylosing spondylitis
• Monoclonal gammopathy of undetermined significance
• Glucocorticoid induced osteoporosis
• Oncology