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Produktdaten

DKK-1

Probenvorbereitung

Centrifuge freshly collected blood as soon as possible Store centrifuged samples at -20°C for longer storage. Samples are stable up to 3 freeze and thaw cycles. Hemolyzed or lipemic samples may cause erroneous results.

Referenzwerte

Serumproben von Blutspendern zeigten eine mittlere DKK-1 Konzentration von 35 pmol/l (n= 51) Median 36 pmol/l (SD 15 pmol/l)

Produktname DKK-1 - Dickkopf-1
Kat-Nr. BI-20413
Bereich 0 – 160 pmol/l
Sensitivität 1.25 pmol/l (STD2 10 pmol/l)
Inkubationszeit 3.5 hours
Probenmenge 20 µl
Probentyp

Serum

Spezies

Human

Tests 96
Methode ELISA

Anwendung

Intendet use:

Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression. DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.

Intended applications:

  • Atherosclerosis
  • Rheumatoid arthritis
  • Myeloma bone disease
  • Diffuse idiopathic skeletal hyperostosis
  • Ankylosing spondylitis
  • Monoclonal gammopathy of undetermined significance
  • Glucocorticoid induced osteoporosis
  • Oncology

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