Knochenstoffwechsel
Produktdaten
DKK-1
Probenvorbereitung
Centrifuge freshly collected blood as soon as possible Store centrifuged samples at -20°C for longer storage. Samples are stable up to 3 freeze and thaw cycles. Hemolyzed or lipemic samples may cause erroneous results.
Referenzwerte
Serumproben von Blutspendern zeigten eine mittlere DKK-1 Konzentration von 35 pmol/l (n= 51) Median 36 pmol/l (SD 15 pmol/l)
| Produktname | DKK-1 - Dickkopf-1 |
| Kat-Nr. | BI-20413 |
| Bereich | 0 – 160 pmol/l |
| Sensitivität | 1.25 pmol/l (STD2 10 pmol/l) |
| Inkubationszeit | 3.5 hours |
| Probenmenge | 20 µl |
| Probentyp | Serum |
| Spezies | Human |
| Tests | 96 |
| Methode | ELISA |
Anwendung
Intendet use:
Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression. DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.
Intended applications:
- Atherosclerosis
- Rheumatoid arthritis
- Myeloma bone disease
- Diffuse idiopathic skeletal hyperostosis
- Ankylosing spondylitis
- Monoclonal gammopathy of undetermined significance
- Glucocorticoid induced osteoporosis
- Oncology