Knochenstoffwechsel

Produktname

DKK-1

Dickkopf-1

Kat-Nr.BI-20413
Bereich0 – 160 pmol/l
Sensitivität1.25 pmol/l (STD2 10 pmol/l)
Inkubationszeit3.5 hours
Probenmenge20 µl
Probentyp

Serum

Probenvorbereitung

Centrifuge freshly collected blood as soon as possible
Store centrifuged samples at -20°C for longer storage.
Samples are stable up to 3 freeze and thaw cycles.
Hemolyzed or lipemic samples may cause erroneous results.

Referenzwerte

Serumproben von Blutspendern zeigten eine mittlere DKK-1
Konzentration von 35 pmol/l (n= 51)
Median 36 pmol/l (SD 15 pmol/l)

Spezies

Human

Tests96
MethodeELISA
Anwendung

Intended use:

Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression.
DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.

Intended applications:

Atherosclerosis
Rheumatoid arthritis
Myeloma bone disease
Diffuse idiopathic skeletal hyperostosis
Ankylosing spondylitis
Monoclonal gammopathy of undetermined significance
Glucocorticoid induced osteoporosis
Oncology

Produktinformation

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