Bone metabolism

Product name

CICP/PICP MicroVue™ Quidel®

C-terminal Propeptide of Collagen Type-I

Range1 - 80 ng/ml
Sensitivity0.2 ng/ml
Incubation time4 hours
Sample volume25 µl (dilute 1:12)
Sample type

Serum, Heparin- and EDTA Plasma and cell culture

Sample preparation

Avoid hemolysis of specimens. Keep samples refrigerated at 
2-8°C for storage of less than 5 days. For longer storage freeze specimens at -20°C or below.

Reference values
Gender  Range (ng/ml)
Women 69 - 147
Men 76 - 163

Reference values from children are available.


Human, rabbit, cynomolgus macaque, porcine

Tests96 Tests
Intended use

The CICP Kit provides a quantitative method for the determination of collagen production. Collagen type-I is indicative for the collagen production in vivo. As the primary organic constituent of bone, type-I collagen levels have been linked to bone growth and formation. Elevated levels of CICP have been shown in diseases associated with high levels of bone turnover including Paget’s disease, hyperthyroidism, primary hyperparathyroidism and renal osteodystrophia. Frequently, the marker protein CICP has been used in growth deficient children and children with bone diseases. In addition, when metastases of cancer occur to sites in bone and/or liver, a greater proportion of individuals show elevated CICP levels in comparison to patients with other or without metastases.

Product informations

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