Product name

Collagen IV, Human serum

Novel Liver Injury Biomarkers

Range15.6 – 1000 μg/l
Sensitivity15.6 μg/l
Incubation time1 hour
Sample volume50 μl
Sample type


Sample preparation

Samples can be stored at 2 – 8 °C for one week
Samples may be stored at -20 °C for 12 months.
Repeated freeze-thawing of samples should be avoided.

Reference values

99 ± 23 μg/l (Mean ±1 SD, N= 180)



Cross reaction

Cross reactivity is less than 2 % with Collagen II and less than 0.5 % with other forms of collagen.



No significant interference has been observed in this assay with lipaemic, haemolytic or icteric samples.

  • Lipaemia: Less than 10 % interference up to 1200 Formazine turbidity units.
  • Haemolysis: Less than 10 % interference up to 3 g/l haemoglobin.
  • Icteris: Less than 10 % interference up to 0.2 g/l bilirubin.
Intended use
  • Chronic liver disease comprises a number of progressive disorders which culminate in liver cirrhosis and which are characterized by excessive deposition of collagen.
  • Collagen IV deposition increases in the liver with the progression of fibrosis and this increase is directly correlated in rising serum levels. Serum Collagen IV levels have been demonstrated to be an effective marker of disease progression and also therapeutic efficacy in several disorders such as hepatitis C patients and abstaining alcoholics.
Product informations

Back to overview