Bone metabolism

Product name

PYD and DPD (Quidel®)

Pyridinolin- and Deoxypyridinolin-Crosslinks

Free DPD and free PYD

Range15 - 750 nmol/l
Sensitivity7.5 nmol/l
Incubation time4 hours
Sample volume50 µl (dilute 1:10)
Sample type

Urine, cell culture

Sample preparation

Use preservative-free first or second morning urine. In case of longitudinal studies, urine should be collected at the same time every day. Store samples refrigerated at 2-8°C for a maximum of 7 days. For longer storage, freeze specimens at -20°C or below.

Reference values
  Range (nmol/mmol Cr) average (nmol/mmol Cr)
 Premenopausal women 16.0 - 37.0 25.5
Men 12.8 - 25.6 18.5




Human, mouse, rat, guinea pig, rabbit, porcine, dog, sheep, horse, cynomolgus macaque, rhesus macaque

Cross reaction

< 2.5 % with PYD and DPD peptides

Tests96 Tests
Intended use

Crosslinks of mature type-I collagen in bone are the pyridinium crosslinks pyridinoline (PYD) and deoxypyridinoline (DPD). PYD and DPD are formed by the enzymatic action of lysyl oxidase on the amino acid lysine. They are released into the circulation during the bone resorption process. Pyridinium crosslinks are excreted unmetabolized in urine and are unaffected by diet, making them suitable for assessing resorption.

Product informations

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