Collagen resorption. C-Terminus of 3/4 peptide, generated through cleavage of types I and II collagens by collagenases

Sample preparation

Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples.
Serum: stable > 1 year at -70 °C.

Product name C1,2C
Cat-Nr. 60-1002-001
Range 0.03 - 10 µg/ml
Incubation time 2.5 hours
Sample volume 25 μl (dilute serum 1:2)
Sample type

Serum (also used for plasma, urine, cell culture, tissue, synovial fluid, cartilage extracts, bronchoalveolar lavage)


Human (also used for dog, bovine, horse, mouse, rhesus macaque, rat, guinea pig, sheep). The use of rabbit samples may lead to high background interference.

Cross reaction

Negligible cross-reaction with uncleaved triple-helical and heat-denatured human collagen types I and II and intact or cleaved alpha-chains of collagen type-II.

Tests 96 Tests
Method ELISA

Intended use

C1,2C as a biomarker is used in the investigation of the progression of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, reflecting cartilage, ligament, skin, synovium/capsule, lung and bone damage or inflammation or repair, in human as well as some animal models. Increased serum C1,2C concentrations give an indication of a rapid progressive joint damage in RA.

Product informations