C1,2C
Produktdaten
Collagen resorption. C-Terminus of 3/4 peptide, generated through cleavage of types I and II collagens by collagenases
Sample preparation
Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples.
Serum: stable > 1 year at -70 °C.
| Product name | C1,2C |
| Cat-Nr. | 60-1002-001 |
| Range | 0.03 - 10 µg/ml |
| Incubation time | 2.5 hours |
| Sample volume | 25 μl (dilute serum 1:2) |
| Sample type | Serum (also used for plasma, urine, cell culture, tissue, synovial fluid, cartilage extracts, bronchoalveolar lavage) |
| Species | Human (also used for dog, bovine, horse, mouse, rhesus macaque, rat, guinea pig, sheep). The use of rabbit samples may lead to high background interference. |
| Cross reaction | Negligible cross-reaction with uncleaved triple-helical and heat-denatured human collagen types I and II and intact or cleaved alpha-chains of collagen type-II. |
| Tests | 96 Tests |
| Method | ELISA |
Intended use
C1,2C as a biomarker is used in the investigation of the progression of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, reflecting cartilage, ligament, skin, synovium/capsule, lung and bone damage or inflammation or repair, in human as well as some animal models. Increased serum C1,2C concentrations give an indication of a rapid progressive joint damage in RA.