Bone metabolism

Product name

NTX-Urine (Osteomark®)

N-Terminal Telopeptide of Type I Collagen

Range20 - 3000 nM BCE
Sensitivity20 nM BCE (value not corrected for creatinine)
Incubation time2 hours
Sample volume25 µl
Sample type

Urine, cell culture

Sample preparation

Collect second void of morning urine or 24 hours urine without adding preservatives. Fasting sample collection is not required.
Samples are stable at room temperature for 24 hours or refrigerated
at 2-8 °C for up to 72 hours. Longer storage at -20°C. Stable up to 3 freeze and thaw cycles.

Reference values

nmol Bone Collagen Equivalents/l (nM BCE)
per mmol Creatinine/l = nM BCE / mM Creatinine


  Mean Range (± 2 SD)
Premenopausal women (25 - 49 yrs) 35 5 - 65
Men (31 - 87 yrs) 33 3 - 63


Reference values from children are available.


Human, dog, porcine, rat, bovine and rhesus macaque

Tests96 Tests
Intended use

Osteomark® NTX-Urine test is used for the quantitative measured of cross-linked N-telopeptides of type I collagen in urine. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.

NTX-levels are used for:
• monitoring of antiresorptive therapy in osteoporosis
• Paget’s disease.
• monitoring and early detection of bone metastasis.

Product informations

Back to overview