NTX-Urine
Produktdaten
N-Terminal Telopeptide of Type I Collagen
Sample preparation
Collect second void of morning urine or 24 hours urine without adding preservatives. Fasting sample collection is not required.
Samples are stable at room temperature for 24 hours or refrigerated
at 2-8 °C for up to 72 hours. Longer storage at -20°C. Stable up to 3 freeze and thaw cycles.
Reference values
nmol Bone Collagen Equivalents/l (nM BCE)
per mmol Creatinine/l = nM BCE / mM Creatinine
| Mean | Range (± 2 SD) | |
| Premenopausal women (25 - 49 yrs) | 35 | 5 - 65 |
| Men (31 - 87 yrs) | 33 | 3 - 63 |
Reference values from children are available.
| Product name | NTX-Urine |
| Cat-Nr. | 9006 |
| Range | 20 - 3000 nM BCE |
| Sensitivity | 20 nM BCE (value not corrected for creatinine) |
| Incubation time | 2 hours |
| Sample volume | 25 µl |
| Sample type | Urine, cell culture |
| Species | Human, dog, porcine, rat, bovine and rhesus macaque |
| Tests | 96 Tests |
| Method | ELISA |
Intended use
NTX-Urine test is used for the quantitative measured of cross-linked N-telopeptides of type I collagen in urine. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.
NTX-levels are used for:
- monitoring of antiresorptive therapy in osteoporosis
- Paget’s disease
- monitoring and early detection of bone metastasis
