Oxidative Stress & Cardiovascular Disease

Product name

oLAB IgG

Human IgG autoantibodies against oxidized low densitiy lipoprotein

Cat-Nr.BI-20032
Range37-1200 mU/ml
Sensitivity48 mU/ml
Incubation time1,5 h at 37°C / 30 min at RT / 15 min at RT
Sample volume50 µl
Sample type

serum

Sample preparation

Centrifuge freshly collected blood as soon as possible. Samples should be stored at -20°C, for long time storage store at -70°C.

Reference values

Median: 263 mU/ml (n=50)

Species

Human

Tests96
MethodELISA
Intended use

Oxidizied low densitiy lipoprotein (oLDL) plays a critical role in the development and progression of atherosclerosis. Accumulation of oLDL in macrophages and smooth muscle cells causes foam cell formation, an initial step in the disease. Autoantibodies against oxidatively modified LDL can be used as a parameter that consistently mirrors the occurrence of oxidation processes taking place in vivo. In fact, elevated levels of autoantibodies against oLDL have been detected in the blood stream of patients with coronary artery disease. Moreover, recent studies indicate a correlation between autoantibodies against oLDL and the progression of carotid atherosclerosis. Increased serum concentrations of oLAB have also been described in various diseases such as pre-eclampsia and systemic lupus erythematosus. Decreased oLAB titers were observed during septicemia and myocardial infarction.

Clinical significance:
• atherosclerosis
• coronary artery disease
• risk stratification from myocardial infarction
• acute septicemia

Product informations

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