Kidney disease

Product name

KIM - 1, Human urine

Kidney Injury Biomarker for proximal tubular damage

Cat-Nr.H-RENA-E-001
Range0.31 - 10 ng/ml
Sensitivity0.01 ng/ml
Incubation time3.5 hours
Sample volume50 μl
Sample type

Urine (Suggested initial dilution of 1:3)

Sample preparation

4 °C for up to four days or -20 °C for longer periods.

Species

Human

Intended use

Kidney Injury Molecule-1 (KIM-1) is a type I trans-membrane structural glycoprotein expressed on epithelial cells of the renal proximal tubule. KIM-1 is undetectable in healthy tissue but its expression is highly induced in response to toxic and ischemic injury. The ectodomain of KIM-1 is shed into the urine in response to these injuries making it an early and specific biomarker for acute kidney injury (AKI).

Intended use:

The KIM-1 EIA provides a method for the quantitative determination of KIM-1 in human urine. KIM-1 has demonstrated excellent value as a pre-clinical tool for monitoring drug induced nephrotoxicity. In the clinical setting KIM-1 has been investigated as a marker of AKI onset in nephrotoxicity studies, cardiothoracic surgery and in the intensive care setting. KIM-1 has also been investigated as a biomarker of nephropathy status in chronic disorders such as diabetes.

Product informations

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