Diabetes & Obesity

Product name

Adiponectin high sensitive ELISA (TECO®)

Total Human Adiponectin

Cat-Nr.TE1013
Range1 – 100 ng/ml native Adiponectin
Sensitivity< 0.6 ng/ml
Incubation time2 hours
Sample volume5 µl (dilute >1:300 serum and plasma). For other biological fluids see protocol.
Sample type

Serum, heparin plasma, breast milk, urine, saliva, CSF, cell culture

Sample preparation

Blood collection - fasting is recommended.
Samples are stable for maximum 2 days at room temperature. Long-term storage stable for maximum 2 years at -20 °C.
Max. 5 freeze and thaw cycles.

Reference values
  mg/l
Men Adult 8-10
Female Adult 10-12
cut-off 10


Comprehensive clinical reference data related to age and gender are available for this test.

Species

Human

Tests96
MethodELISA
Intended use

Adiponectin is a 30kDa protein and its percentage in serum proteins is 0.01%. In vivo, it appears with different oligomers and it is mainly synthesized by adipocytes. Until now, IGF-1 is the only known natural inductor of synthesis.
Low Adiponectin levels are closely associated with insulin resistence and metabolic syndrome as well as an increased risk of type 2 diabetes mellitus and cardiovascular disease.
Today, Adiponectin is thought to act as an endogenic insulin sensitizer by decreasing excessive glucose levels without increasing insulin concentrations and by stimulating the burning of adipose tissue in muscle and liver.
Adiponectin is associated with glucose and lipid metabolism and is assumed to have direct antiatherogenic characteristics. Furthermore, it is involved in inflammatory processes.

Clinical significance:
• Obesity
• Atherosclerosis
• Energy metabolism
• Coronary artery disease
• Metabolic syndrome
• Polycystic ovary syndrome (PCOS)

Product informations

Adiponectin is mainly synthesized by adipocytes, but also in muscle cells and hepatocytes. Until now, IGF-I is the only known natural inductor of the synthesis. Adiponectin correlates with BMI and is associated with the Insulin-Resistance and therefor linked with Type II Diabetes. Adiponectin is also associated with glucose- und lipometabolism. Furthermore Adiponectin is involved in inflammatory processes and is of importance for the appearance of arteriosclerosis and coronaritis. Our Total Human Adiponectin ELISA is suited for the determination of Adiponectin in human plasma and serum.

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