Cartilage metabolism

Product name

C1,2C

Collagen resorption. C-Terminus of 3/4 peptide, generated through cleavage of types I and II collagens by collagenases

Cat-Nr.60-1002
Range0.03 - 10 µg/ml
Incubation time2.5 hours
Sample volume25 μl (dilute serum 1:2)
Sample type

Serum (also used for plasma, urine, cell culture, tissue, synovial fluid, cartilage extracts, bronchoalveolar lavage)

Sample preparation

Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples.
Serum: stable > 1 year at -70 °C.

Species

Human (also used for dog, bovine, horse, mouse, rhesus macaque, rat, guinea pig, sheep). The use of rabbit samples may lead to high background interference.

Cross reaction

Negligible cross-reaction with uncleaved triple-helical and heat-denatured human collagen types I and II and intact or cleaved alpha-chains of collagen type-II.

Tests96 Tests
MethodELISA
Intended use

C1,2C as a biomarker is used in the investigation of the progression of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, reflecting cartilage, ligament, skin, synovium/capsule, lung and bone damage or inflammation or repair, in human as well as some animal models. Increased serum C1,2C concentrations give an indication of a rapid progressive joint damage in RA.

Product informations

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