Calcium metabolism

Product name

Klotho, Human

Cat-Nr.27998
Range93.75 - 6000 pg/mL
Sensitivity6.15 pg/mL
Incubation time2 hours
Sample volume100 ┬ÁL
Sample type

Serum, EDTA plasma, urine

Sample preparation

Collection, testing and samples storage should take place promptly. Store samples at -20 °C or below. Avoid repeated freezing and thawing of specimens.

Reference values

239 – 1266 pg/mL

Species

Human

Specificity

No cross-reactions observed with: osteopontin, human VEGF or PDGF.

Tests96
MethodELISA
Intended use

Klotho is a single-pass trans-membrane anti-aging protein (1014 amino-acids, 130 kDa, chromosomic location in 13q12 in humans) that has been recently shown to have wide and important biological effects. Its expression occurs mainly in the kidney and in the parathyroid. Its extra-cellular domain is wide whereas its intra-cellular part is very short; it also exists as a soluble protein.

In humans, Klotho polymorphisms have been associated both in a positive and negative way to bone mineral density, life expectancy, cardiovascular events (e.g., ischemic stroke, carotid atherosclerosis), biomarkers of metabolic syndrome (e.g., uric acid levels, lipid and glucose metabolisms), and even to cognitive ability.

Product informations

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