Calcium metabolism

Product name

FGF-23 (C-Term) Mouse

Fibroblast Growth Factor 23

Cat-Nr.60-6300
Range30 – 1000 pg/ml (can be extended to 3000 pg/ml)
Sensitivity4 pg/ml
Incubation time3.5 hours
Sample volume25 µl
Sample type

EDTA & heparin plasma, cell culture

Sample preparation

FGF-23 molecule is very unstable. Therefore samples should be assayed immediately or stored frozen at -20°C or below. Avoid repeated freeze/thaw cycles.

Species

Mouse, rat, canine, porcine

Tests96
MethodELISA
Intended use

FGF-23 Fibroblast Growth Factor 23

FGF-23 is produced in osteoblast precursor cells and is a potent regulator of phosphate and vitamin D metabolism.

Phosphate plays an essential role in the stability of skeletal bones and energy metabolism as well as in DNA synthesis and intracellular signal cascades.

FGF-23 inhibits in combination with cofactor Klotho phosphate reabsorption in renal proximal tubular cells via FGF-23 receptors (increased phosphate loss, reduced serum phosphate) and decreases calcitriol synthesis by suppressing alpha-1-hydroxylase.

Product informations

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