Bone metabolism

Product name

sRANKL, Human, high sensitive

Soluble, non-complexed Human sRANKL

Cat-Nr.BI-20452
Range0.125 - 2 pmol/l (1 pg/ml = 0.05 pmol/l)
Sensitivity0.02 pmol/l = 0.4 pg/ml
Incubation timeOvernight plus 1.5 hours
Sample volume100 ┬Ál
Sample type

Serum, plasma (EDTA, Heparin), cell culture

Sample preparation

Store samples at -20 °C or below if not assayed on the same day.
Maximum 4 freeze/thaw cycles. Before use, thaw samples at low temperature and mix them thoroughly. Lipemic or hemolyzed samples may give erroneous results.

Reference values

 

  Median (pmol/l)
females 0.37
males  0.46

 

Species

Human, porcine

Tests96 Tests
MethodELISA
Intended use

sRANKL, soluble receptor activator of nuclear factor (NF)-kB ligand (also: Osteoprotegerin ligand, OPGL) a member of the tumor necrosis factor (TNF) family, is the main stimulatory factor for the formation of mature osteoclasts and is essential for their survival. RANKL is produced by osteoblastic lineage cells and activated T lymphocytes. It activates its specific receptor RANK that is located on osteoclasts and dendritic cells. The effects are counteracted by OPG. Human sRANKL corresponds to free and OPG-bound RANKL. sRANKL is one of the key molecular regulation system for bone remodeling. An increase in RANKL expression leads to bone resorption and bone loss.

Indication:

  • Postmenopausal and senile Osteoporosis
  • Glucocorticoid-induced Osteoporosis
  • Diseases with locally increased resorption activity
  • Therapy control of OPG treatments
  • Arthritis
  • Bone Metastases
Product informations

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