Monoklonale Antikörper

A murine monoclonal antibody to an epitope in the C3d domain of C3

Specifications:
Isotype: IgG1k
Protein Concentration: > 1.0 mg/ml
Volume/Vial: 100 µl
Storage: 2-8°C

Specificity:
This monoclonal antibody was raised against purified human C.
It is specific for an antigen expressed on the C3d domain of C3 and therefore reactive to C3 and all C3d-containing fragments of C3.

Applications:
Quidel's C3 (C3d) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, and Immunohistochemistry.

References:

• Tamerius, J.D., M. Pangburn, et al., Detection of a neoAntigen on human iC3b and C3d by monoclonal Antibody, J. Immunol. 135:2015 (1985).
• Tamerius, J.D., M.k. Pangburn, et al., Selective inhibition of functional sites of cell bound C3b by hybridoma derived antibodies, J. Immunol 128:512, (1982).
• Rogers, J., N. Cooper, et al., Complement Activation by ß-amyloid in Alzheimer disease. PNAS 89:10016-10020 (1992).
• Gemmell, C., A flow cytometric immunoassay to quantify adsorption of complement activation products on artificial surfaces, J Biomed Mater Res 37, 474-480 (1997)
• Stoltzner, S., Lemere, C. et al., Temporal accrual of complement proteins in Amyloid plaques in patients with Down syndrome with Alzheimer's Disease, Am J Path 156:489-499, (2000).