Monoclonal Antidodies

A murine monoclonal antibody to an epitope in the Bb fragment of
Factor B

Specifications:
Isotype: IgG1k
Protein Concentration: > 1.0 mg/ml
Volume/Vial: 100 µl
Storage: 2-8°C

Specificity:
This monoclonal antibody was raised against purified human Factor B. It is specific for an antigen expressed on the Bb domain of Factor B and therefore reactive to Factor B and the Bb fragment of Factor B. This antibody inhibits the function of Factor B in vitro.

Applications:
Quidel's Factor B (Bb) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry.

References:

• Ann Wright, S Morrison., Effect of C2 Associated Carbohydrate structure of Ig Effector function: studies with chimeric mouse human IgG1 Antibodies in glycosylation mutants of chinese hamster ovary cells, J. Immunol 160:3393-3402, 1998.
• D. Hourcade, et al., A conserved element in the serine protease domain of complement Factor B, J Bio Chem 273:25996-26000, 1998.