Monoclonal Antidodies

A murine monoclonal antibody to human C4d containing fragments

Specifications:
Isotype: IgG1k
Protein Concentration: > 1.0 mg/ml
Volume/Vial: 0.5 ml
Storage: 2-8°C

Specificity:
This monoclonal antibody was raised against purified human C.
It is specific for an antigen expressed on the C4d domain of C4 and therefore reactive to C4 and all C4d-containing fragments of C4.

Applications:
Quidel's C4d monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry and Immunohistochemistry.

References:

• Rogers, J., N. Cooper, et al., Complement Activation by ß-amyloid in Alzheimer disease, PNAS 89:10016-10020 (1992).
• Schwab, C. Steele, JC. McGeer, PL., Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins, Brain Res. 707(2):196-20r (1996).
• Gemmell, C., A flow cytometric immunoassay to quantify adsorption of complement activation products on artificial surfaces, J Biomed Mater Res 37, 474-480, (1997).
• S. Solzner, Lemerre, C. et al., Temporal accural of complement proteins in Amyloid plaques in patients with Down syndrome with Alzheimer's Disease, Am J Path 156:489-499, (2000).