Factor I is a fluid phase complement regulatory enzyme. It consists of two peptide chains with molecular weights of 50kD and 38 kD respectively. Factor I is present in plasma at 35 mg/L. With Factor H, CR1 or C4 Binding Protein acting as a co factor, Factor I cleaves the C3b subunit of the alternative and classical pathway convertases, thereby inactivating them.
Specifications:
Concentration: 1.0 mg/ml
Volume/Vial: 250 µl/vial
Storage: at or below -70°C
Purity: > 95%
Buffer: PBS
Functional Testing:
All Quidel complement components are tested for functional activity in a standard lytic or applicable functional assay and for biochemical purity by SDS- polyacrylamide gel electrophoresis. Please refer to the Certificate of Analysis for lot specific information on functional titer.
Applications:
Quidel's purified human complement components are useful in a wide variety of immunochemical and research applications. |
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