| Anwendung |
Factor D is unique to the Alternative Complement Pathway. It consists of a single peptide chain with a molecular weight of 24 KD. Factor D is a specific serine protease which cleaves Factor B complexed with C3b (or hydrolyzed C3) in a single position to yield Bb and Ba.
Specifications:
Concentration: 0.1 mg/ml
Volume/Vial: 250 µl/vial
Storage: at or below -70°C
Purity: > 95%
Buffer: PBS
Functional Testing:
All Quidel complement components are tested for functional activity in a standard lytic or applicable functional assay and for biochemical purity by SDS- polyacrylamide gel electrophoresis. Please refer to the Certificate of Analysis for lot specific information on functional titer.
Applications:
Quidel's purified human complement components are useful in a wide variety of immunochemical and research applications.
References:
- R. Marks, Hindmarsh, E., Complement activation occurs on subendothelial extracelluslar matrix in vitro and is initiated by retraction or removal of overlying endothelial cells, J Immunol 160:6128-6136, 1998.
- S. Barbashov, Wang C., Nicholson-Weller, A., Serum amyloid P component forms a stable complex with human C5b-6, J. Immunol. 158:3830-3835 (1997).
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