| Anwendung |
Complement component C7 is unique to the terminal complement pathway. It is a single chain protein with a molecular weight of 110 KD and is present in plasma at approximately 55 mg/L. Together with the other proteins of the terminal pathway, C7 forms the membrane attack complex or MAC.
Specifications:
Concentration: 1.0 mg/ml
Volume/Vial: 250 µl/vial
Storage: at or below -70°C
Purity: > 95%
Buffer: PBS
Functional Testing:
All Quidel complement components are tested for functional activity in a standard lytic or applicable functional assay and for biochemical purity by SDS- polyacrylamide gel electrophoresis. Please refer to the Certificate of Analysis for lot specific information on functional titer.
Applications:
Quidel's purified human complement components are useful in a wide variety of immunochemical and research applications.
References:
- Nicholson-Weller, Butko, P, Wessels, M., Role of Complement Component C1q in IgG independent Opsonophagocytosis of Group B Streptococus, J. Immunol 163:2761-2768, 1999.
- S. Barbashov, Wang C., Nicholson-Weller, A., Serum amyloid P component forms a stable complex with human C5b-6, J. Immunol. 158:3830-3835 (1997).
- C. Koski, Dashell, S., Sublytic terminal complement complex decreases Po gene expression in schwan cells, J Neurochem 73(6):2321-2330 (1999).
- C. Liu, et al., Interaction between the terminal complement pathway complex C5b-7 and anionic phospholipids, Blood 93(7)2291-2301(1999).
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