Growth metabolism

Productname	IGF-I
	Insulin like Growth Factor – I (IGFBP blocked)
Cat-No.	E20
Range	42 – 1050 ng/ml (after dilution 1:21)
Sensitivity	0.09 ng/ml
Incubation time	2 hours RT
Calibration	WHO NIBSC 02/254
Sample volume	10 µl (dilute 1:21)
Sample type	Serum, plasma, CSF and other human body fluids/ cell culture media.
Sample preparation	Samples have to be chilled as soon as possible after collection. Long-term storage should be carried out at –20°C or below. Avoid repeated freezing/thawing of specimens.
Reference values	IGF-I serum concentration is the main parameter in growth diagnostics. Critical for correct interpretation of measured IGF-I values is the consideration of age and gender dependency of IGF-I concentration. A detailed table is included in the product brochure.
Species	Human, primates, bovine, porcine, sheep, horse, donkey, goat, dog, cat, rabbit, guinea pig
Tests	96 Tests
Method	ELISA
Product informations	- Kit Instructions (pdf-File 403 kb) - Cross-reaction all species (pdf-File 71 kb)
Intended use	IGF-1 is a low molecular weight peptide which promotes cellular mitosis and differentiation in a variety of tissues. In nanism due to congenital GH deficiency or GH resistance, as well as in later forms of GH deficiency a decrease in circulating IGF-I can be observed. This also causes a decrease in serum levels of IGFBP-3 (GH dependent). On the other hand GH hypersecretion (gigantism, acromegaly) causes increased IGF-1 and IGFBP-3 levels.