| Productname |
 SC5b-9 Plus MicroVue™ Quidel® |
|
Quantification of the SC5b-9 complex |
| Cat-No. |
A029 |
| Range |
10 - 170 ng/ml |
| Sensitivity |
LOD: 3.7 ng/ml; LLOQ: 8.8 ng/ml |
| Incubation time |
2 hours |
| Sample volume |
10 µl (dilute 1:40 for serum); 50 µl (dilute 1:10 for plasma) |
| Sample type |
Serum, EDTA plasma, spinal fluid or other biological fluids |
| Sample preparation |
The proper collection and storage of specimens is essential since SC5b-9 may be generated in improperly handled specimens. Serum or EDTA plasma specimens should be collected aseptically using standard techniques.
They should be tested immediately or stored at 4 ºC or on ice until assayed. This should not exceed four hours. For longer-term storage freeze at -70 ºC. Plasma concentrations better reflect in vivo concentrations in comparison to serum concentrations. |
| Reference values |
Serum 334 - 1672 ng/ml
EDTA Plasma 127 - 303 ng/ml |
| Species |
Human, cynomolgus macaque, baboon, rhesus macaque |
| Specificity |
Monoclonal mouse-antibody, specifically binds SC5b-9. |
| Tests |
96 Tests |
| Method |
ELISA |
| Product informations |
- Literature: Complement Diagnostics (pdf-File 1,850 kb)
- Kit Instructions (pdf-File 185 kb)
- Cross-reaction all species (pdf-File 71 kb)
- Datasheet (pdf-File 511 kb)
- Information (pdf-File 680 kb)
- Information: Monitoring Complement Activation SC5b-9, C5a &CH50 (pdf-File 100 kb)
|
| Intended use |
The SC5b-9 enzyme immunoassay measures the amount of SC5b-9 present in human plasma, serum and other biological or experimental samples.
The Terminal Complement Complex (TCC, SC5b-9) is generated by the assembly of C5 through C9 as a consequence of activation of the complement system by either the classical, lectin or alternative pathway. The membrane attack complex (MAC), a form of TCC, is a stable complex that mediates the irreversible target cell membrane damage associated with complement activation. |
| Keywords product |
SC5b-9 Plus, ELISA, SC5b-9 Complex, Terminal complement pathway, Biocompatibility, Hemocompatibility, Complement pathway, Complement cascade, ASTM F1984-99, ASTM F2065-00
|
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