Cartilage metabolism Product details
| Productname |
C1,2C |
|
Collagen resorption. C-Terminus of 3/4 peptide, generated through cleavage of types I and II collagens by collagenases |
| Cat-No. |
60-1002 |
| Range |
0.03 - 10 µg/ml |
| Incubation time |
2.5 hours |
| Sample volume |
25 μl (dilute serum 1:2) |
| Sample type |
Serum (also used for plasma, urine, cell culture, tissue, synovial fluid, cartilage extracts, bronchoalveolar lavage) |
| Sample preparation |
Serum samples should be aliquoted, rapidly frozen and stored at -70 °C. Avoid repeated freezing/thawing of samples.
Serum: stable > 1 year at -70 °C. |
| Species |
Human (also used for dog, bovine, horse, mouse, rhesus macaque, rat, guinea pig, sheep). The use of rabbit samples may lead to high background interference. |
| Cross reaction |
Negligible cross-reaction with uncleaved triple-helical and heat-denatured human collagen types I and II and intact or cleaved alpha-chains of collagen type-II. |
| Tests |
96 Tests |
| Method |
ELISA |
| Product informations |
- Kit Instructions (pdf-File 79 kb)
- Cross-reaction all species (pdf-File 71 kb)
- Bone & Cartilage Metabolism (pdf-File 2,480 kb)
- Cartilage Monograph (pdf-File 512 kb)
- Information: RA Biomarkers (pdf-File 329 kb)
- Information: OA Biomarkers (pdf-File 235 kb)
|
| Intended use |
C1,2C as a biomarker is used in the investigation of the progression of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, reflecting cartilage, ligament, skin, synovium/capsule, lung and bone damage or inflammation or repair, in human as well as some animal models. Increased serum C1,2C concentrations give an indication of a rapid progressive joint damage in RA. |
| Keywords product |
C1-2C, ELISA, Cartilage Degradation, Cartilage Degradation marker, Rheumatoid Arthritis, Osteoarthritis, Cartilagemarker, Therapy efficiency |
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