Calcium metabolism Product details

Productname	Klotho, Human
Cat-No.	27998
Range	93.75 - 6000 pg/mL
Sensitivity	6.15 pg/mL
Incubation time	2 hours
Sample volume	100 µL
Sample type	Serum, EDTA plasma
Sample preparation	Collection, testing and samples storage should take place promptly. Store samples at -20 °C or below. Avoid repeated freezing and thawing of specimens.
Reference values	239 – 1266 pg/mL
Species	Human
Specificity	No cross-reactions observed with: osteopontin, human VEGF or PDGF.
Tests	96
Method	ELISA
Product informations	- Kit Instructions (pdf-File 203 kb) - Cross-reaction all species (pdf-File 71 kb) - Bone & Cartilage Metabolism (pdf-File 1,005 kb) - Information: Laboratory Parameters Nephrology and Dialysis (pdf-File 199 kb) - Information: FGF23 and Klotho (pdf-File 214 kb)
Intended use	Klotho is a single-pass trans-membrane anti-aging protein (1014 amino-acids, 130 kDa, chromosomic location in 13q12 in humans) that has been recently shown to have wide and important biological effects. Its expression occurs mainly in the kidney and in the parathyroid. Its extra-cellular domain is wide whereas its intra-cellular part is very short; it also exists as a soluble protein. In humans, Klotho polymorphisms have been associated both in a positive and negative way to bone mineral density, life expectancy, cardiovascular events (e.g., ischemic stroke, carotid atherosclerosis), biomarkers of metabolic syndrome (e.g., uric acid levels, lipid and glucose metabolisms), and even to cognitive ability.