Calcium metabolism Product details

Productname	FGF-23 (C-Term) Mouse
	Fibroblast Growth Factor 23
Cat-No.	60-6300
Range	30 – 1000 pg/ml (can be extended to 3000 pg/ml)
Sensitivity	4 pg/ml
Incubation time	3.5 hours
Sample volume	25 µl
Sample type	Serum, plasma, cell culture
Sample preparation	FGF-23 molecule is very unstable. Therefore samples should be assayed immediately or stored frozen at -20°C or below. Avoid repeated freeze/thaw cycles.
Species	Mouse, rat, canine, porcine
Tests	96
Method	ELISA
Product informations	- Kit Instructions (pdf-File 46 kb)
Intended use	FGF-23 Fibroblast Growth Factor 23 FGF-23 is produced in osteoblast precursor cells and is a potent regulator of phosphate and vitamin D metabolism. Phosphate plays an essential role in the stability of skeletal bones and energy metabolism as well as in DNA synthesis and intracellular signal cascades. FGF-23 inhibits in combination with cofactor Klotho phosphate reabsorption in renal proximal tubular cells via FGF-23 receptors (increased phosphate loss, reduced serum phosphate) and decreases calcitriol synthesis by suppressing alpha-1-hydroxylase.