| Intended use |
TRAP5b is highly specific for osteoclasts in-vivo, although it has been shown to be secreted by alveolar macrophages under certain conditions. As a bone marker, TRAP5b is unique in that it reflects the number of osteoclasts and, as changes in bone resorption are usually associated with changes in osteoclast number, TRAP5b is a useful indicator of bone resorption.
TRAP5b is not linked specifically to osteoclast mediated collagen degradation, rather it is secreted by active osteoclasts whether or not they are metabolizing bone substrate. In certain disease states where bone resorption and the number of active osteoclasts is uncoupled, this may be very significant. TRAP5b data may also be seen as supportive of other resorption data indicating an increase in the number of active osteoclasts. |
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