Bone metabolism Product details
| Productname |
 PYD and DPD (Quidel®) |
|
Pyridinolin- and Deoxypyridinolin-Crosslinks
Free DPD and free PYD |
| Cat-No. |
8010 |
|
4823 PYD Control (Urine) Set of 4 x 0.5 ml (4 levels)
Average: 38, 118, 236, 492 nM |
| Range |
15 - 750 nmol/l |
| Sensitivity |
7.5 nmol/l |
| Incubation time |
4 hours |
| Sample volume |
50 µl (dilute 1:10) |
| Sample type |
Urine, cell culture |
| Sample preparation |
Use preservative-free first or second morning urine. In case of longitudinal studies, urine should be collected at the same time every day. Store samples refrigerated at 2-8°C for a maximum of 7 days. For longer storage, freeze specimens at -20°C or below. |
| Reference values |
| |
Range (nmol/mmol Cr) |
average (nmol/mmol Cr) |
| Premenopausal women |
16.0 - 37.0 |
25.5 |
| Men |
12.8 - 25.6 |
18.5 |
|
| Species |
Human, mouse, rat, guinea pig, rabbit, porcine, dog, sheep, horse, cynomolgus macaque, rhesus macaque |
| Cross reaction |
< 2.5 % with PYD and DPD peptides |
| Tests |
96 Tests |
| Method |
ELISA |
| Product informations |
- Kit Instructions (pdf-File 190 kb)
- Animal reference Values (pdf-File 25 kb)
- Children reference Values (pdf-File 400 kb)
- Cross-reaction all species (pdf-File 71 kb)
- Cell culture (pdf-File 93 kb)
- Bone & Cartilage Metabolism (pdf-File 2,480 kb)
|
| Intended use |
Crosslinks of mature type-I collagen in bone are the pyridinium crosslinks pyridinoline (PYD) and deoxypyridinoline (DPD). PYD and DPD are formed by the enzymatic action of lysyl oxidase on the amino acid lysine. They are released into the circulation during the bone resorption process. Pyridinium crosslinks are excreted unmetabolized in urine and are unaffected by diet, making them suitable for assessing resorption. |
| Keywords product |
Pyrilinks, Pyd+Dpd, ELISA, Pyridinolin- and Desoxypyridinolin-Crosslinks, Type I collagen, Rheumatoid arthritis, Bone resorption, Bone marker |
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