| Productname |
 NTX-Urine (Osteomark®) |
|
N-Terminal Telopeptide of Type I Collagen |
| Cat-No. |
504837 |
| Range |
20 - 3000 nM BCE |
| Sensitivity |
20 nM BCE (value not corrected for creatinine) |
| Incubation time |
2 hours |
| Sample volume |
25 µl |
| Sample type |
Urine, cell culture |
| Sample preparation |
Collect second void of morning urine or 24 hours urine without adding preservatives. Fasting sample collection is not required.
Samples are stable at room temperature for 24 hours or refrigerated
at 2-8 °C for up to 72 hours. Longer storage at -20°C. Stable up to 3 freeze and thaw cycles. |
| Reference values |
nmol Bone Collagen Equivalents/l (nM BCE)
per mmol Creatinine/l = nM BCE / mM Creatinine
| |
Mean |
Range (± 2 SD) |
| Premenopausal women (25 - 49 yrs) |
35 |
5 - 65 |
| Men (31 - 87 yrs) |
33 |
3 - 63 |
Reference values from children are available.
|
| Species |
Human, dog, porcine, rat, bovine and rhesus macaque |
| Tests |
96 Tests |
| Method |
ELISA |
| Product informations |
- Kit Instructions (pdf-File 259 kb)
- Cross-reaction all species (pdf-File 71 kb)
- Cell culture (pdf-File 93 kb)
- Bone & Cartilage Metabolism (pdf-File 2,480 kb)
|
| Intended use |
Osteomark® NTX-Urine test is used for the quantitative measured of cross-linked N-telopeptides of type I collagen in urine. The NTX molecule is bone specific due to the unique amino acid sequences of the cross-linked alpha-2 (I) N- telopeptide. Release of the NTX molecule is mediated by osteoclasts. Elevated levels of NTX indicate elevated bone resorption.
NTX-levels are used for:
• monitoring of antiresorptive therapy in osteoporosis
• Paget’s disease.
• monitoring and early detection of bone metastasis.
|
| Keywords product |
NTX urine, ELISA, N-terminal telopeptide, Type-I-collagen, Bone resorption, antiresorptive Therapy, Osteoporosis, Paget's disease, Early detection of bone metastasis, Bone marker |
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