Bone metabolism Product details
| Productname |
 BAP MicroVue™ Quidel® |
|
Bone-specific Alkaline Phosphatase, Enzyme activity of bound BAP is measured |
| Cat-No. |
8012 |
| Range |
2-140 U/l (1-70 µg/l) |
| Sensitivity |
0.7 U/l |
| Incubation time |
3.5 hours |
| Sample volume |
20 µl |
| Sample type |
Heparinized plasma, serum, cell culture |
| Sample preparation |
Plasma samples should not be treated with EDTA or citrate because of the inhibition of the BAP enzyme. Keep samples refrigerated at 2-8°C for storage of less than 5 days. For long-term storage freeze specimens at -20°C or below. |
| Reference values |
| |
U/L |
| Female (25 - 44 years Premenopausal) |
11.6 - 29.6 |
| Female (≥ 45 years Postmenopausal) |
14.2 - 42.7 |
| Male (> 25 years) |
15.0 - 41.3 |
Reference values from children are available. |
| Species |
Human, rabbit, porcine, dog, cat, sheep, goat, bovine, horse, baboon, rhesus macaque, cynomolgus macaque |
| Cross reaction |
Minimal cross-reactivity to liver (3 – 8%), intestinal (0.4%) and placental (0%) alkaline phosphatases. |
| Tests |
96 Tests |
| Method |
ELISA |
| Product informations |
- Literature: BAP Monograph (pdf-File 1,118 kb)
- Kit Instructions (pdf-File 193 kb)
- Animal reference Values (pdf-File 25 kb)
- Children reference Values (pdf-File 400 kb)
- Cross-reaction all species (pdf-File 71 kb)
- Cell culture (pdf-File 93 kb)
- Datasheet (pdf-File 131 kb)
- Bone & Cartilage Metabolism (pdf-File 2,480 kb)
- Information: Laboratory Parameters Nephrology and Dialysis (pdf-File 199 kb)
|
| Intended use |
BAP (bone specific alkaline phosphatase) is a highly specific marker of osteoblast activity during bone remodeling. Measurement of BAP is intended for use as an aid in:
- management of postmenopausal osteoporosis and Paget’s disease.
- monitoring postmenopausal women on hormonal or bisphosphonate therapy.
- predicting skeletal response to hormonal therapy in postmenopausal women.
- diagnostic analysis metastasis.
See also reference: Clinical & Technical Monograph: Bone specific alkaline phosphatase (BAP). |
| Keywords product |
BAP, ELISA, Bone-specific alkaline phosphatase, Bone remodeling, Bone formation Paget's disease, Bone turnover, Postmenopausal osteoporosis, Therapy efficiency, Bone metastasis, Bone marker, Osteoporosis therapy prim./sec., Hyperparathyroidism |
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