Diabetes & Obesity Product details

Productname	Resistin
Cat-No.	E50
Range	20 – 1000 pg/ml
Sensitivity	12 pg/ml
Incubation time	4 hours
Sample volume	15 µl (dilute 1:21; recommended)
Sample type	Serum, plasma, cell culture medium, salvia, breast milk and urine.
Sample preparation	Haemolytic samples appear to show falsely high Resistin levels. Whole blood should be chilled as soon as possible following collection. Serum and plasma samples are stable for maximal 2 days at room temperature. Long-term storage at -20°C, stable for maximal 2 years. Maximum 3 freeze/thaw cycles.
Reference values	Women: 7.0 ng/ml +/- 2.5 SD (referred to BMI ~ 25 kg/m²) Men: 6.0 ng/ml +/- 2.5 SD (referred to BMI ~ 25 kg/m²)
Species	Human
Tests	96 Tests
Method	ELISA
Product informations	- Literature: Metabolic Syndrome (Diabetes) Monograph (pdf-File 540 kb) - Kit Instructions (pdf-File 407 kb) - Cross-reaction all species (pdf-File 71 kb)
Intended use	Resistin (FIZZ3) is a hormone influencing fat metabolism and inflammation processes. In humans, it is expressed in bone marrow and transported by macrophages into adipose tissue. Resistin stimulates pre-adipocyte proliferation and lipolysis of mature adipocytes probably by influencing MAPK signaling. With regard to the importance of Resistin in disorders of energy metabolism, a significant reduction could be shown in patients with anorexia nervosa. It has been demonstrated that Resistin enhances the expression of specific cell markers such as VACM-1 and ICAM-1 and thus may influence endothelial inflammatory processes, and thereby arteriosclerosis. Moreover, due to its association with Endothelin-1, Resistin also plays a role in cardiovascular diseases. Resistin is relevant to medical conditions such as: • Obesity • Insulin resistance, diabetes • Arteriosclerosis • Inflammation • Lipolysis

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